Spravato® (Esketamine) Treatment in Fort Myers
Spravato® is an FDA-approved nasal spray medication for adults with treatment-resistant depression or major depressive disorder with suicidal thoughts. At Mentus Health in Fort Myers, Spravato® is offered in a safe, private, supervised clinical setting and is covered by most insurance plans.
If traditional antidepressants haven’t worked, Spravato® may offer a new path forward.
What Is Spravato®?
Spravato® (esketamine) is used in combination with an oral antidepressant for adults with:
- Treatment-resistant depression (TRD)
- Major depressive disorder (MDD) with suicidal thoughts or behavior
Unlike traditional antidepressants that primarily affect serotonin, Spravato® works on the NMDA/glutamate system, a different brain pathway that may produce faster symptom relief in some patients.
Spravato® vs. Ketamine Therapy
Spravato® is often grouped with “ketamine therapy,” but there are important differences:
| Spravato® | IV ketamine clinics |
|---|---|
| FDA-approved for depression | Off-label for depression; not FDA-approved for this use |
| Nasal spray under REMS supervision | IV infusion |
| Often covered by most insurance plans | Cash-pay only |
| Structured medical setting | Varies by clinic |
At Mentus Health, we offer Spravato® specifically, not IV ketamine infusions.
What to Expect During Treatment
Spravato® is administered in-clinic under strict FDA REMS supervision.
At Mentus Health, patients are treated in a private, comfortable room designed to feel calm and supportive. Our clinical team remains nearby throughout your entire visit.
Treatment process
- Check-in and clinical review
- Self-administer nasal spray under supervision
- 2-hour monitored observation period
- Discharge once stable
You must have a ride home and cannot drive after treatment.
Treatment schedule
- Weeks 1–4: typically twice weekly
- Then: once weekly
- Then: every other week or monthly (maintenance phase)
Treatment frequency is adjusted based on symptom improvement and clinical response.
Who Is a Candidate?
Spravato® may be appropriate for adults who:
- Have tried at least two antidepressants without adequate improvement
- Are experiencing major depressive disorder with suicidal thoughts or behavior
All patients complete a comprehensive psychiatric evaluation at Mentus Health to determine eligibility and safety.
Insurance & Cost
Spravato® is often covered by insurance when criteria are met.
Unlike most IV ketamine clinics, which are cash-pay only, Mentus Health helps make treatment more accessible by:
- Verifying insurance benefits
- Completing prior authorizations
- Submitting required clinical documentation
Eligible patients may also qualify for savings programs such as Janssen CarePath.
View accepted insurance plansIntegrated care at Mentus Health
Spravato® at Mentus Health is not a standalone service — it is part of a full psychiatric treatment model.
Patients receive:
- Medication management
- Therapy and ongoing support
- Long-term psychiatric follow-up
- Coordinated care from one clinical team
This ensures continuity before, during, and after Spravato® treatment — rather than fragmented care across multiple providers.
Learn more about depression treatment, our full services, and the providers who administer Spravato®.
Frequently asked questions
Is Spravato® safe?
Yes. It is FDA-approved and administered under a strict REMS safety program with medical supervision during every session.
How long does treatment take?
Each session lasts about 2 hours including monitoring.
Can I drive after treatment?
No. You must arrange transportation after each session.
Does insurance cover Spravato®?
Many insurance plans do when medical criteria are met. Our team helps with verification and authorization.
Take the Next Step
If you’re struggling with depression that hasn’t improved with standard treatments, Spravato® may be an option.
12651 McGregor Blvd. Suite No. 301 · Fort Myers, FL 33919